IL4 gene polymorphism and previous malaria experiences manipulate anti-Plasmodium falciparum antibody isotype profiles in complicated and uncomplicated malaria
نویسندگان
چکیده
منابع مشابه
Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria
To examine human gene expression during uncomplicated P. falciparum malaria, we obtained three samples (acute illness, treatment, and recovery) from 10 subjects and utilized each subject's recovery sample as their baseline. At the time of acute illness (day 1), subjects had upregulation of innate immune response, cytokine, and inflammation-related genes (IL-1β, IL-6, TNF, and IFN-γ), which was ...
متن کاملThe Use of Crude Plasmodium falciparum Antigens for Comparison of Antibody Responses in Patients with Mild Malaria vs. Cerebral Malaria
Background: Cerebral malaria (CM) is one of the major causes of death in African populations infected with Plasmodium falciparum. Only 1% of infected subjects develop CM. The reasons for these differences are not fully understood, but it is likely that the host humoral response against blood-stage antigens plays a role in protection from malaria, although the precise targets and mechanisms medi...
متن کاملTreatment of Uncomplicated Plasmodium falciparum Malaria
Background: This paper reports for the first time, the antimalarial efficacy of a five-day course of paediatric formulation of “vocamine” named MMH8 from Millenia Hope Inc for the treatment of uncomplicated Plasmodium falciparum malaria. Methods: We used the standard 14-day WHO protocol to assess therapeutic responses in children less than 5 years in Bangui (Central African Republic) between Ja...
متن کاملEfficacy of mefloquine treatment and genetic profiles in uncomplicated Plasmodium falciparum malaria in southern Lao PDR.
We conducted a 28-day follow-up of 17 Laotian patients diagnosed with uncomplicated Plasmodium falciparum malaria treated with mefloquine (Mephaquine, MQ) alone to determine the efficacy. All patients were completely cured with MQ, without reappearance of asexual stage parasitemia at follow-up. Of the 7 isolates tested for genotypic analysis, one isolate was a Y86 mutant type of the pfmdr1 gene...
متن کاملArtemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria
The World Health Organization strongly recommends artemisinin-based combination therapy (ACT) regimens for the treatment of uncomplicated Plasmodium falciparum malaria cases in endemic areas. Among the combinations of compounds that are available at present, excellent results have been obtained for the artemisinin derivative artemether, in a combination galenic preparation with lumefantrine (ar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Malaria Journal
سال: 2009
ISSN: 1475-2875
DOI: 10.1186/1475-2875-8-286